Use of human diploid cell MRC - 5, for production of Measles and Rubella virus vaccines
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A comparative field trial of five measles vaccines produced in human diploid cell, MRC-5.
Five batches of experimental measles vaccines were prepared with Biken-CAM, Schwarz, Sugiyama, Leningrade-16 and AIK-C strains in MRC-5 HDC. The rct 40, T50 or neurovirulence for baby hamsters of these viruses adapted to HOC were not significantly changed but the neurovirulence of the Sugiyama virus for day-old hamsters was increased after passages in HOC. Whith the exception of the AIK-C strai...
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volume 31 issue 1
pages 97- 102
publication date 1979-02-01
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